Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia
نویسندگان
چکیده
منابع مشابه
Skeletal muscle loss: cachexia, sarcopenia, and inactivity.
Loss of skeletal muscle mass occurs during aging (sarcopenia), disease (cachexia), or inactivity (atrophy). This article contrasts and compares the metabolic causes of loss of muscle resulting from these conditions. An understanding of the underlying causes of muscle loss is critical for the development of strategies and therapies to preserve muscle mass and function. Loss of skeletal muscle pr...
متن کاملSTAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
BACKGROUND Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6), and the presence of the acute phase response. Acute phase proteins, including fibri...
متن کاملThe Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...
متن کاملRunning head: Stress and muscle cachexia Stress and Muscle Cachexia
One of the metabolic hallmarks of sepsis and severe injury is muscle cachexia, mainly reflecting increased protein breakdown, in particular myofibrillar protein breakdown. This review describes recent knowledge regarding the molecular mechanisms of sepsis-induced muscle cachexia. Among different intracellular proteolytic pathways, the energy-ubiquitindependent pathway is particularly important ...
متن کاملCancer Cachexia: Muscle Physiology and Exercise Training
Cachexia in cancer patients is a condition marked by severe tissue wasting and a myriad of quality of life and health consequences. Cachexia is also directly linked to the issues of morbidity and survivability in cancer patients. Therapeutic means of mitigating cachexia and its effects are thus critical in cancer patient treatment. We present a discussion on the use of physical exercise activit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2018
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2018.05.026